F-35 operations resumed at the Marine Corps Air Station in Yuma over the weekend after the fighter jets had been grounded for two days.
The temporary grounding was so engineers could fix a software glitch. The software is part of a ground-based system military officials call the information technology backbone of the F-35.
The jets have been grounded in Arizona twice this month. Operations were temporarily canceled at Luke Air Force Base in Glendale after pilots reported symptoms related to oxygen deprivation.
The Air Force and Marines fly different F-35 models, both made by Lockheed Martin.
